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In conclusion, our study has provided evidence supporting that the HGF/c-Met signaling pathway promotes PNI in pancreatic cancer by activating the mTOR/NGF axis and increasing the invasion and migration ability of pancreatic cancer cells (Fig
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This synergy was documented in human subjects by Veldhuis and Bowers in the American Journal of Physiology Endocrinology and Metabolism in 2009, via simultaneous 3-hour IV infusions of GHRH and GHRP-2 at 1 mcg/kg/h each following a 3-hour saline baseline in 47 men aged 18 to 74
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