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Neuroimaging is a non-invasive modality that may assist in answering structural, functional, and mechanistic questions, complementary to the in vivo animal, histological, and hematological studies and human clinical trials that have been discussed in response to PYC intervention
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Under normal physiological conditions, the glycolytic activity of TECs remains low, and ATP generated through aerobic glycolysis accounts for only a minor proportion (∼4%) of total ATP production ( During AKI, mitochondrial FAO and the transport of FAs into mitochondria are significantly impaired due to mitochondrial dysfunction and disruption of quality control mechanisms ( During both early and late reperfusion phases following IR injury, there is a notable increase in glucose uptake and glycolytic activity in the renal cortex
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