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Enzymes involved in GDP-mannose synthesis: phosphomannose isomerase, phosphomannose mutase, and GDP-mannose pyrophosphorylase A nexus of enzymes synthesizes a range of GDP-sugars [GDP-Man, GDP-l-Fuc, GDP-l-Gal, and GDP-l-gulose (l-Gul)] involved in protein glycosylation and glycan and sphingolipid synthesis in the ER and Golgi apparatus (Baldwin et al

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Indeed, ingestion of 15–25 g of APAP is fatal in a quarter of cases due to acute liver failure (Larson et al., 2005)