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however, in in vitro cultured macrophage models, high concentrations of leucine can enhance anti-inflammatory gene expression through mechanistic target of mTORC1 signaling, which is inconsistent with other theoretical views and suggests that its effects are condition-dependent ( In addition to energy supply and metabolic flux remodeling, amino acid-derived metabolites can also directly participate in signaling regulation

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These three papers, alongside the foundational 2005 Jetté paper on the hGRF(1-29)-albumin parent (PMID 15817669), form the core pharmacology stream