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Following an ADC binding to its antigen target, an ADC-antigen complex is formed, which is internalized by the tumor cell via endocytosis in three steps, (1) bud formation, (2) membrane curvature and vesicle maturation and (3) scission and release of the membrane into the cytoplasm (Fig
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The clinical trials that led to FDA approval demonstrated consistent reductions in visceral adipose tissue, measured by imaging
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