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Evidence for a role of oxidative stress in populations with schizophrenia includes polymorphisms in key GSH pathway genes and altered levels of antioxidants (with correlations between levels and severity of symptoms).75 Oxidative stress may lead to changes in lipid membranes, mitochondrial dysfunction and alterations to DNA and proteins

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Since GSSG is then enzymatically reduced by glutathione reductase, GSH is the dominant form in organisms