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To date, clinical trials of single-agent anti-IGF-1R mAbs and IGF-1R TKIs have been disappointing, reporting low objective response rates and with only minor responses and disease stabilization in most tumor types (Table 1) [58, 59, 62, 81–96]
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FIGURE 1 Glutathione S -transferase P1 is also involved in cell death regulation, interacting with apoptotic signaling pathways as for example c-Jun NH2-terminal kinase (JNK1), ERK1/ERK2, or tumor necrosis factor receptor-associated factor 2 (TRAF2
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