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Consistent with our previous results (Figure 2) and downregulated the expression of carnitine-related (Figure 3A) and OXPHOS proteins (Figure 3B) in the skeletal muscle on day 15 of treatment initiation

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The hexenoyl cap sterically blocks dipeptidyl peptidase IV access to the Tyr1-Ala2 cleavage site while preserving the full 44-amino-acid sequence and the pulsatile GHRH-receptor signaling mode of the native parent [1] [2]