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A placebo-controlled 10-person study examined a four-week treatment with 0.5% Ectoin in the crow's feet area and found a significant anti-wrinkle effect (-19% mean wrinkle depth) in 100% of the participants
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However, some molecules or drugs, such as erastin, sulfasalazine, sorafenib, and RSL3, are able to block glutathione synthesis or devitalize GPX4
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