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In ventilator-induced lung injury, 4-OI activates Nrf2 and HO-1, suppresses the NLRP3 inflammasome, lowers reactive oxygen species and lipid peroxidation, and mitigates tissue damage

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Glossary 5′-GMP 5′-guanosine monophosphate A375 human melanoma cell line A549 adenocarcinomic human alveolar basal epithelial cell line A2780 human ovarian cancer cell line A2780cisR cisplatin-resistant human ovarian cancer cell line AB Alamar blue Aβ amyloid-β ABTS 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid AD Alzheimer’s disease ATP adenosine triphosphate Bax Bcl-2-associated X protein Bcl2 B-cell lymphoma 2 B-DNA form deoxyribonucleic acid BT-474 human breast cancer cell line ε molar absorption coefficient ESI electrospray ionization CD3CN deuterated acetonitrile COLO-205 human colorectal adenocarcinoma cell line COLO-320 human colorectal adenocarcinoma multidrug resistant expressing ABCB1 (MDR1)-LRP cell line CCK8 cell counting kit-8 CP8 cisplatin-resistant human ovarian cancer cell line CT-DNA calf thymus DNA D2O heavy water DCFDA 2′,7′-dichlorofluorescein diacetate DFT density functional theory DLD-1 human colorectal adenocarcinoma cell line DMEM Dulbecco’s modified eagle medium DMSO dimethyl sulfoxide DPPH 1,1-diphenyl-2-picrylhydrazyl DPPIV dipeptidyl peptidase IV DU-145 human prostate carcinoma cell line EC50 half maximal effective concentration ESI-MS electrospray ionisation mass spectrometry FAO Food and Agriculture Organisation FDA Food and Drug Administration FGF-2 soluble basic fibroblast growth factor FITC-PI fluorescein isothiocyanate-propidium iodide FT-ICR-MS Fourier transform ion cyclotron resonance mass spectrometry GLP-1 glucagon-like peptide 1 GSH glutathione GSTP1 glutathione S-transferase P1 HaCaT human keratinocyte cell line HCT116 human colorectal carcinoma cell line HeLa human cervical carcinoma cell line HEK-293 human embryonic kidney 293 cell line HEK-293T human embryonic kidney 293T cell line Hep3B human hepatocellular carcinoma cell line HepG2 human liver cancer cell line HL-60 human promyelocytic leukemia cell line HEWL hen egg white lysozyme HPL1D human peripheral lung epithelial cell line HPLC high-performance liquid chromatography HRMS high-resolution mass spectrometry HSA human serum albumin IC50 half-maximal inhibitory concentration ICP-MS inductively coupled plasma mass spectrometry IR infrared spectroscopy 3J and 4J coupling constant to three or four bonds JNK c-Jun N-terminal kinases JURKAT human T lymphocyte cell line Ki inhibitory constant λmax maximum wavelength log PO/W logarithm of the octanol-water partition coefficient LnCaP human prostate cancer cell line (lymph node carcinoma of the prostate) LnCaP-SF LNCaP steroid-free m/z mass-to-charge ratio M-1 cm-1 molar inverse centimetre inverse MB methylene blue MCF-7 breast cancer cell line (michigan cancer foundation-7) MCF-10A normal breast epithelial cell line MDA-MB-231 human breast cancer cell line (M