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Multiple studies consistently suggest that the chronic over-reactive MC mediator production and release in most MCAS patients, both at baseline and in reaction to triggers, are driven principally by a large menagerie of (mostly somatic) variants in regulatory genes within the dysfunctional MCs [45]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Fang F., Yang W., Florio J.B., Rockenstein E., Spencer B., Orain X.M., Dong S.X., Li H., Chen X., Sung K., et al