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This happens due to cross-reactivity between S protein and self-antigens resulting in antigen presentation by antigen-presenting cells through major histocompatibility class II (MHC class II) to CD4+ T cells [146,147]
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It stimulates pulsatile growth-hormone release from pituitary somatotrophs without significant effect on ACTH, cortisol or prolactin in published models — the basis for its classification as a ‘selective GHRP’
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