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Benfotiamine, used at a dose of 600 mg/day in a one-year long randomized, placebo-controlled trial in patients with Alzheimer’s disease, showed good tolerability and therapeutic efficacy that also reduced blood levels of markers of glycation and glycation end-products [51]

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Consequently, the development of safe and effective pharmacological agents that integrate antioxidant capacity with immunomodulatory activity represents a promising and strategically important direction for future MS therapies