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The vast majority of the excitatory neurons in your nervous system—including your brain and spinal cord—are glutamatergic, which means they are activated by glutamate

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Emerging evidence indicates that vitamin D, through receptor-mediated signaling, participates in multiple pathophysiological processes, including the regulation of immune and inflammatory responses, the mitigation of oxidative stress, the preservation of mitochondrial function, the inhibition of renal fibrosis, modulation of the renin–angiotensin–aldosterone system (RAAS), and the maintenance of gut–kidney axis homeostasis